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W., Raman A
Despite being a pivotal regulatory node in tumor cell therapy response, non-selective inhibition of CUL5 may trigger undesirable off-target effects
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Acetyl coenzyme A (acetyl-CoA) is a pivotal metabolite in lipid metabolism, serving essential roles in the synthesis of fatty acids, cholesterol, and proteins [23]
However, whereas the majority of hepatotoxic compounds cause centrilobular injury, some xenobiotics, such as allyl formage, elemental phosphorus, and allyl alcohol, preferentially damage periportal hepatocytes, presumably as a result of rapid first-pass uptake by these upstream hepatocytes
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