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Notably, TNBC tumors with high-circadian rhythm disruption score were associated with decreased melatonin biosynthesis and increased tryptophan metabolism, associating melatonin suppression with immune evasion and poor relapse-free survival 197

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2014;164A(2): 421424

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The phenomenon of enzyme induction ensures increased availability of the particular CYP isoform that is appropriate for the substrate in question