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The mechanism appears to involve increased serotonin synthesis in substantia nigra (both compacta and reticulata), a regional pattern unlike any existing antidepressant drug, plus potential dopaminergic contributions given the nigrostriatal location
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During aging, vital organs including the heart, liver, and kidneys undergo degenerative changes
Diarrhea peaks during the first 5 days of each dose escalation and resolves within 3-4 weeks at stable dosing
No body composition change yet
So the goal of the B12 component is correction and prevention: keeping levels from dropping during treatment, which can in turn help offset the fatigue, brain fog, and irritability that may otherwise show up around weeks 4 to 8 of GLP-1 treatment
Wolff law dictates that bone adapts to the forces placed upon it, and this applies during fracture repair as well
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