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34 The efficacy of e-cigarettes in smoking cessation Quitting smoking by stopping abruptly or by gradual reduction with or without aids such as nicotine replacement therapy (NRT) and/or support 35 has, until the 2013 National Institute for Care and Health Excellence (NICE) guidance on tobacco harm reduction, 36 been the main approach to reducing tobacco consumption

Both the IOM and FDA have cited the necessity of examining the effects of potential MRTPs on the health of individual tobacco users and the population as a whole to determine MRTPs possible contribution to tobacco harm reduction

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10.1111/j.1749-6632.1972.tb40178.x 6