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GLP-1 RAs are recommended in the treatment guidelines by the American Diabetes Association as well as the American Association of Clinical Endocrinology (AACE) Consensus Statement & European Society of Cardiology for type 2 diabetes mellitus patients with co-morbidities, like established atherosclerotic cardiovascular disease and obesity

That dose, adjusted for human weight, would be roughly 1,600 mg for an average adult, far exceeding any practical use by orders of magnitude

337(a) (as described above)

In animal studies, side effects have been minimal and mostly gastrointestinal

Lgr5-expressing chief cells drive epithelial regeneration and cancer in the oxyntic stomach

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