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Of the 225 subjects with schizophrenia, 40 were first-episode and treatment-naive, while the remaining 185 schizophrenia subjects were recurrent (had psychotic episodes in the past) and had not taken any antipsychotic drugs for at least 1 month prior to hospitalization

That said, oral supplementation is not without value when sustained over longer periods

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Anhedonia requires MC4R-mediated synaptic adaptations in nucleus accumbens

Additionally, systemic tolerability especially gastrointestinal side effects remains a challenge: a too-rapid release early on will cause a burst of drug and thus nausea

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