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Tirzepatide has an obviously lower affinity with GIPR than GIP does (pIC 50 : 6.70 vs 7.87), and its cAMP activity is approximately equal to that of GIP

PMC 10619894

Mouse embryos possessing a non-functional MET receptor result in short, less branched spinal sensory nerves and apoptotic sympathetic neuroblasts in vivo (Maina et al., 1997, 1998

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discussion S47-8, DOI:10.1002/ana.10479, PMID 12666097