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Low doses of tamoxifen act as agonists in IGF-1-stimulated breast cancer cells and further increase IGF-1 expression

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249,250,251,252,253,254,255,256 The soluble receptor proteins are linked to the ER through specific ER-resident proteins such as vesicle-associated membrane protein-associated protein A/B (VAPA/VAPB), TRIM13, or the ubiquitin-fold modifier 1 (UFM1)-DDRGK domain containing 1 (DDRGK1) complex

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