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Your age, health, and lifestyle can change how often you need B12 injections

However, allergic reactions to B12 shots are extremely rare

If you have a temporary deficiency or increased requirement (say, after a surgery or during recovery from an acute illness), you might only need a short course, perhaps a few weeks of injections, until your vitamin levels normalize or you can meet your needs by mouth again

We usually test before starting treatment, then after 1-3 months

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Unlike other vitamins, Vitamin B12 absorption is dependent on a protein called intrinsic factor