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NAD + depletion, as seen in aging and certain diseases, is linked to mitochondrial dysfunction, impaired oxidative metabolism, and decreased repair capacity 3,4

54 Furthermore, in the allyl alcohol and APAP mouse models with vitamin E deficiency, there were up to 50-fold increases in ethane and pentane exhalation, which correlated with severe liver injury

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95% CI, 3.3 to 7.7 lb [1.5 to 3.5 kg]) greater than placebo for the 120-mg and 60-mg doses, respectively

Regulates the increase in nitric oxide production post-workout, to reduce fatigue