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Association of PTPN22 1858C/T polymorphism with vitiligo susceptibility in Gujarat population

Consultado el 15 de diciembre de 2009

During chronic infections, increased levels of proinflammatory cytokines such as TNF-, IFN- and IL-6 together with increased CD8 T cell activation can trigger muscle catabolism and even cachexia, promoting the degradation of muscle proteins for energy or amino acids (178180)

Energetically favorable literally means that it has a more negative Gibbs free energy, which typically means that the protein is more compact and makes more interactions with itself, like in the rough sketch of a protein on the right side of Figure 6