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Finally, because selection might take place at other X-linked loci, heterozygotes exhibiting extreme phenotypes by analysis of G6PD may arise from selection acting on an allele at another locus (a hitchhiking effect), as has been suggested in a family with G6PD Ilesha

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Additionally, AST upregulates miR-29a-3p expression, further inhibiting these signaling pathways, reinforcing its anti-tumor activity in NPC treatment