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Materials and Methods Drugs and chemicals All chemicals used were of the highest available purity and were obtained from Roth (Karlsruhe, Germany), Sigma-Aldrich (Steinheim, Germany), or Merck (Darmstadt, Germany)

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They work intracellularly to block the JAK/STAT signaling pathway, effectively intercepting the downstream signaling of multiple pro-inflammatory cytokines that drive RA tofacitinib mono-therapy has been found to be superior to methotrexate in reducing the symptoms and progression of RA

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Neuroinflammation in Alzheimer disease