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Synapses will strengthen for a short time because of an increase in the amount of packaged transmitter released in response to each action potential

Buettner C, Nir RR, Bertisch SM, et al

This isn't just training-floor folklore

Common effects usually mild and often worst during titration include nausea, vomiting, diarrhea, constipation, abdominal pain, upset stomach, headache, and fatigue

JinG-ZYuW-LDongHZhouW-PGuY-JYuHet al

The reduction in subarachnoid bleeding is also relevant for hemorrhagic stroke, where bleeding into the space surrounding the brain causes both direct pressure damage and inflammatory toxicity