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It is also not recommended for some people with a history of pancreatitis

Warning signs requiring immediate medical attention include severe abdominal pain (especially radiating to the back or right upper quadrant), persistent vomiting preventing oral intake, fever, jaundice, or signs of dehydration

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Semaglutide acid reflux and compounded formulations Many semaglutide users obtain their medication through compounding pharmacies rather than brand-name products

Your provider can work with you to find a semgalutide dose that works for you

Trial participants on the highest dose lost roughly 15% of body weight over 68 weeks, a number so far above what any prior pharmacotherapy had achieved that endocrinologists who had spent careers managing modest expectations had to recalibrate the conversation in real time