Rescue experiments using the Wnt agonist BML-284 reverted the phenotypic change in both EMT markers, restoring the cancer phenotype and confirming the signalling pathway-specific mechanism of caudatin action (Figure 2)
Aliberti, J., Hieny, S., Reis e Sousa, C., Serhan, C
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Dyrk1b knock-down with small interfering RNA suggests that DYRK1B is the major mediator of this signaling pathway in enteroendocrine cells
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