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Both hGH and its C-terminal fragment reduce body weight gain, increase fat oxidation, and stimulate lipolysis in obese mice, yet AOD9604 does not interact with the hGH receptor Unfortunately, the AOD-904 results in human clinical trials didnt show the same level of promise

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Both UDCA and glycine-conjugated ursodeoxycholic acid (GUDCA) function as FXR antagonists (105)

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Full laboratory and genomic information were not available for study participants, thereby limiting other clinical correlations and additional understanding of underlying pathophysiology